» Pharmaceutical Raw » Nootropics » Urolithin B powder
| Molecular Formula | C13H8O3 |
| Molecular Weight | 212.204 |
| CAS number | 1139-83-9 |
| Specifications | 98%, 99% |
| Appearance/color | brown-yellow powder to white powder |
| Solubility | DMSO: 250 mg/mL (1178.13 mM) |
| Benefits | Bodybuilding for muscle builder, muscle growth |
| Application | sports nutrition, dietary supplements, cosmetics |
| Dosage | 300mg |
Urolithin B, derived from pomegranate peels, is a phenolic compound found in the human gut after absorption of ellagitannins-containing foods such as pomegranate extract, strawberries, walnuts, or oak-aged red wine. It has anti-inflammatory and antioxidant effects. Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and Akt, and enhances the phosphorylation of AMPK. Urolithin B is also a regulator of skeletal muscle mass.
There is no recommended dose for urolithin supplement for the time being. There are no stand-alone urolithin B supplements. Urolithin B is often formulated with other bodybuilding compounds, such as epicatechin and phosphatidylcholine. 300mg urolithin B capsule a day is a popular start.
Reports have shown urolithin B can activate AMPK to increase fat burning and energy expenditure while inhibiting inflammation and oxidative stress.
Urolithin B has been shown to boost protein synthesis and inhibit the ubiquitination-proteasome pathway, which leads to better growth of C2C12 myotubes. Further genetic testing reveals that this occurs via an interaction with the androgen receptor
The details about how urolithin B interacts with AMPK are unknown but it seems like there may be some sort of crosstalk happening between our old friend mTOR (mammalian target of rapamycin) in conjunction with its close associate AMPK.
Urolithin B was found to inhibit protein catabolism, while simultaneously boosting muscle growth. This natural ingredient has been shown in research studies to help build lean muscle and prevent its breakdown.
Urolithin B holds tremendous promise to increase skeletal muscle mass. Clinical research on Urolithin B in mice found that it enhanced myotubes’ growth and differentiation by increasing protein synthesis, a process of building cells from amino acids.
Unlike other supplements which have only shown beneficial effects for weight loss but not necessarily increased muscle mass, urolithin b showed an ability to inhibit the ubiquitination pathway (UPP), the principal mechanism for protein catabolism- or breaking down of proteins into smaller units so they can be eliminated faster.
